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1.
BMC Nurs ; 23(1): 196, 2024 Mar 22.
Artículo en Inglés | MEDLINE | ID: mdl-38519943

RESUMEN

BACKGROUND: Although knowledge of the barriers and motivators to physical activity participation among nurses is increasing, the factors influencing motivation methods' effectiveness are not completely defined. This study aimed to identify the methods that support increasing the level of daily physical activity and the factors that influence the effectiveness of motivation methods among nurses. METHODS: This study was based on an intervention study protocol. All registered nurses in clinical settings were invited to participate in the study. The study involved 71 professionally active nurses. A self-reported questionnaire was used to collect sociodemographic and employment data. The level of physical activity was assessed using the International Physical Activity Questionnaire, and the daily number of steps was assessed using a pedometer. Body composition was measured using a bioimpedance method, and the 5-year risk of cardiovascular events was assessed using the Harvard Score. The intervention included self-monitoring daily steps using a pedometer and completing a diary daily for one month. Additionally, a few-minute speech was sent to each participant via email on the intervention's 7th, 14th, and 21st days. RESULTS: The analysis revealed a higher value of physical activity recorded in the follow-up compared to the initial and final measurement in the Recreation domain [Met] (p < 0.001) and a higher value of daily steps in the follow-up compared to the final measurement (p = 0.005). Participants with a higher Harvard Score were more likely to increase their daily number of steps (OR = 6.025; 95% CI = 1.70-21.41), and nurses working in hospital wards were less likely to do so (OR = 0.002; 95% CI = 0.00-0.41). CONCLUSIONS: Recommendations for physical activity in the nursing population should focus on increasing leisure time physical activity and regular risk assessment of cardiovascular events. A mixed methods approach, such as feedback enhanced by health coaching, effectively achieves long-term physical activity changes in nurses.

2.
Ann Transplant ; 28: e939472, 2023 Oct 03.
Artículo en Inglés | MEDLINE | ID: mdl-37786245

RESUMEN

BACKGROUND Hypertension is a risk factor for graft failure and mortality among kidney transplant recipients (KTRs). The aim of the study was to examine blood pressure (BP) as a factor that contributes to graft failure or death during a 10-year observation period. MATERIAL AND METHODS The study group comprised 70 KTRs who were treated according to their clinical state. Data were collected at 1 month and 1 year after transplantation and included office and ambulatory BP monitoring (ABPM) BP values, eGFR, proteinuria, and BMI. During the observation period, 6 patients died, and 10 lost the graft, but not during the first year. RESULTS Office and ABPM BP values were within normal ranges and did not differ from each other. eGRF and BMI were higher at 1 year compared to 1 month after transplantation, and proteinuria decreased. Among those who died, DBP was lower compared to those of survivors with graft failure. Proteinuria and donor age were positively correlated with BP. CONCLUSIONS Monitoring of BP and adequate treatment of hypertension resulting in BP values within normal values among KTRs contribute to longer survival of the graft and recipient. Older donor age and proteinuria could predict post-transplant hypertension. Low diastolic BP of the recipient could increase the risk of death among KTRs. Despite the fact that ABPM is the blood pressure measurement method of choice, appropriate standard office measurement could also be used for BP monitoring.


Asunto(s)
Hipertensión , Trasplante de Riñón , Humanos , Presión Sanguínea/fisiología , Trasplante de Riñón/efectos adversos , Estudios Retrospectivos , Monitoreo Ambulatorio de la Presión Arterial/efectos adversos , Monitoreo Ambulatorio de la Presión Arterial/métodos , Proteinuria/complicaciones
3.
J Cancer Educ ; 38(5): 1471-1478, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-36973598

RESUMEN

During nursing education, few practical hours are devoted to comprehensively preparing students to care for a dying patient. Contact with a dying patient is a key element of the job of every working nurse in the profession. Therefore, it is necessary to properly prepare nurses to care for a dying patient. This study aimed to assess the professional competence of nurses in caring for a dying patient and the factors that affect this preparation. This study involved 223 nurses during master's degree in nursing at the Medical University of Warsaw, receiving either full-time education (group I, N = 121) or hybrid education (group II, N = 102). The study used the FATCOD-BP ((Frommelt Attitudes Toward the Care Of the Dying scale Form B, Polish version)) questionnaire (Cronbach's alpha 0.75), an original questionnaire containing questions about feelings experienced during the SARS-CoV-2 virus pandemic and sociodemographic questions. FATCOD-BP for all groups was below average regarding caring for a dying patient (M = 109, SD = 11.68). Nurses pursuing full-time education were better prepared to care for a dying patient than were nurses pursuing hybrid education. Nurses who exhibited fear of their own deaths had a lower subjective level of preparation for caring for a dying patient. (1) Nurses are not sufficiently prepared to care for a dying patient. (2) The training of nurses should be provided in the form of in-patient education, and the methods of training should be modified by increasing the number of hours of practical and theoretical instruction in palliative care for a dying patient.


Asunto(s)
COVID-19 , Enfermeras y Enfermeros , Estudiantes de Enfermería , Cuidado Terminal , Humanos , Polonia , Actitud del Personal de Salud , SARS-CoV-2 , Actitud Frente a la Muerte , Encuestas y Cuestionarios
4.
Gerontol Geriatr Educ ; : 1-11, 2022 Sep 12.
Artículo en Inglés | MEDLINE | ID: mdl-36093984

RESUMEN

The demanding and challenging nature of care for geriatric patients requires appropriate preparation of health care professionals. However, the willingness of nursing students to work in geriatric nursing care is mostly at a low level. The EAging_C project has been developed to investigate the relationship between nursing teachers' and students' attitudes towards older people and its impact on career decisions regarding working in a geriatric setting. This study uses an explanatory sequential mixed-method. The study has been conducted in a Polish academic setting in teams of geriatric nursing practical training teachers and their students. Quantitative and qualitative data have been collected in three stages. Kogan's Attitudes Towards Older People questionnaire has been used to collect quantitative data among teachers and students. By developing two questionnaires for the semi-structured interviews (one for students and one for teachers) qualitative data was collected that deepened the quantitative data collected. The investigation conducted in this project allows us to provide an insight into the issue of the unwillingness to work in a geriatric setting by nursing graduates. Based on the identified variables that are crucial to promoting work with older people, further research can be carried out based on testing the intervention.

5.
Med Sci Monit ; 28: e937338, 2022 Aug 09.
Artículo en Inglés | MEDLINE | ID: mdl-35941808

RESUMEN

BACKGROUND Cinacalcet is a calcium-sensing receptor agonist that is clinically approved for the treatment of secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in patients with parathyroid carcinoma. This study aimed to use quantitative mass spectrometry-based label-free proteomics to evaluate the effects of cinacalcet on protein expression in rat brains and livers. MATERIAL AND METHODS We randomly assigned 18 Wistar rats to 2 groups: an untreated control group (n=6) and a group treated with cinacalcet at a dose corresponding to the maximum dose used in humans (2 mg/kg/body weight, 5 days/week) divided into 7-day (n=6) and 21-day (n=6) treatment subgroups. A mass-spectrometry-based label-free quantitative proteomics approach using peptides peak area calculation was used to evaluate the changes in protein expression in examined tissues. Bioinformatics analysis of quantitative proteomics data was done using MaxQuant and Perseus environment. RESULTS No changes in protein expression were revealed in the 7-day treatment subgroup. We detected 10 upregulated and 3 downregulated proteins in the liver and 1 upregulated protein in the brain in the 21-day treatment subgroup compared to the control group. Based on Gene Ontology classification, all identified differentially expressed proteins were indicated as molecular functions involved in the enzyme regulator activity (36%), binding (31%), and catalytic activity (19%). CONCLUSIONS These findings indicate that long-term cinacalcet therapy can impair phase II of enzymatic detoxication and can cause disturbances in blood hemostasis, lipid metabolism, and inflammatory mediators or contribute to the acceleration of cognitive dysfunction; therefore, appropriate patient monitoring should be considered.


Asunto(s)
Proteómica , Receptores Sensibles al Calcio , Animales , Encéfalo/metabolismo , Calcio , Cinacalcet/farmacología , Cinacalcet/uso terapéutico , Humanos , Hígado/metabolismo , Espectrometría de Masas , Naftalenos , Hormona Paratiroidea , Ratas , Ratas Wistar , Receptores Sensibles al Calcio/metabolismo
6.
Artículo en Inglés | MEDLINE | ID: mdl-35742469

RESUMEN

Research indicates that while nurses are aware of the benefits of physical activity (PA), their adherence to PA is low. The results of workplace interventions that increase PA are inconsistent. The study aim was identification the sociodemographic, professional, and incentive factors influencing nurses' PA and investigation its relationship with the level of PA that they report. This study was based on observational cross-sectional research conducted among professionally active nurses working in a clinical setting (n = 350). The self-reported questionnaire was used to collect sociodemographic and employment data and motivators and barriers of participating in PA. The level of PA was assessed using International Physical Activity Questionnaire. The analysis revealed significant differences in the Total Physical Activity Score (TPAS) depending on the variables related to professional activity (working in a management position: p = 0.015; workplace: p = 0.01; shift type: p ≤ 0.002). Cluster analysis revealed that the most important statement in the group division about motivation was fear of the pain occurring after exercise. Nurses who were more motivated to be active showed a higher level of leisure-time PA than less motivated nurses. The recommendation of PA in the nursing population should be focused on increasing the leisure time PA, ensuring the appropriate time to recovery, and compliance with the principles of work ergonomics to prevent musculoskeletal disorders.


Asunto(s)
Ejercicio Físico , Motivación , Estudios Transversales , Humanos , Autoinforme , Encuestas y Cuestionarios , Lugar de Trabajo
7.
Artículo en Inglés | MEDLINE | ID: mdl-35565135

RESUMEN

One way to increase nursing retention is to expand the number of nursing education programs; however, a more cost-effective initial step would be to ensure that each graduate will start a professional career. Nursing studies expose students to prolonged and uncontrolled stress that negatively affects their professional identity and health. Two hundred and fifty-four nursing students participated in this study. The data were obtained using the Perceived Stress Scale (PSS-10), a proprietary questionnaire on the students' perception of their study, intention to practice in the future, and other metrics. Among our sample, a dozen students were unsure that they would enter the nursing profession. Stress levels in women were higher than in men. Respondents indicated that they were afraid of the return of the pandemic. This analysis was significant among people living in large cities. Based on our findings, five themes should be prioritised: favourable study environment and adequate competencies (including implementation of stress management techniques, especially among women and students living and studying in large cities), appropriate working hours, quality of practical classes, and quality of personal protective equipment.


Asunto(s)
Bachillerato en Enfermería , Estudiantes de Enfermería , Ciudades , Estudios Transversales , Femenino , Humanos , Intención , Masculino , Percepción , Encuestas y Cuestionarios
8.
Int J Mol Sci ; 23(8)2022 Apr 11.
Artículo en Inglés | MEDLINE | ID: mdl-35457021

RESUMEN

In many pharmaceuticals, a hydrogen atom or hydroxyl group is replaced by a fluorine to increase bioavailability and biostability. The fate of fluorine released from fluorine-containing drugs is not well investigated. The aim of this study was to examine possible fluorination of proteins in rat liver and brain after administration of the fluorinated drug cinacalcet. We assigned 18 Wistar rats to a control group (n = 6) and a group treated with cinacalcet (2 mg kg-1/body weight, 5 days/week), divided into 7 day (n = 6) and 21 day (n = 6) treatment subgroups. Fluorinated proteins were identified using a free proteomics approach; chromatographic separation and analysis by high-resolution mass spectrometry; peptide/protein identification using the Mascot search algorithm; manual verification of an experimentally generated MS/MS spectrum with the theoretical MS/MS spectrum of identified fluorinated peptides. Three fluorinated proteins (spectrin beta chain; carbamoyl-phosphate synthase [ammonia], mitochondrial; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1) were identified in the liver and four (spectrin beta chain, dihydropyrimidinase-related protein 4, prominin-2, dihydropyrimidinase-related protein 4) in the brain tissue after 21 days of cinacalcet treatment, but not in the control group. Introduction of fluorine into an organism by administration of fluorinated drugs results in tissue-specific fluorination of proteins.


Asunto(s)
Flúor , Halogenación , Animales , Encéfalo , Cinacalcet , Fluoruros , Flúor/química , Hígado , Preparaciones Farmacéuticas , Ratas , Ratas Wistar , Espectrina , Espectrometría de Masas en Tándem
9.
Ann Med ; 54(1): 484-494, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35132927

RESUMEN

BACKGROUND: Novice nurses' responsibilities are greater than what their actual level of competence can cope with. This can cause increased levels of stress, which many studies have shown is a factor resulting in reduced self-esteem, which affects not only the well-being of nurses but also the quality of care provided. AIMS: To investigate the relationship between the self-assessment of nursing competencies and self-esteem among novice nurses and the moderation role of the sociodemographic variables and intention to leave the nursing profession on this relationship. MATERIAL AND METHODS: A correlational cross-sectional study was performed using an online questionnaire. The study was conducted between July and October 2019 among 122 novice nurses. The study tool consisted of the Rosenberg Self-Esteem Scale, the Nurse Professional Competence Scale-Short Version, and metrics. Calculations were performed using SPSS Statistics, version 25. To approach research questions hierarchical multiple regression was performed. RESULTS: The self-esteem level of novice nurses have been identified as low. Novice nurses who declared their willingness to leave their profession had a higher level of self-esteem than nurses who did not declare this willingness. The highest-rated competencies were in the fields of nursing care and value-based nursing care, while the lowest were in the areas of development, leadership, and the organisation of nursing care. Correlations between postgraduate education and competencies in the majority subscales were revealed. The results showed a negative correlation between self-esteem and all subscales of the competence scale. Seniority and postgraduate education were important moderators in the relationship between some competence subscales and self-esteem. CONCLUSION: Novice nurses present a low level of self-esteem. Nurses with a higher competence level showed lower self-esteem. Developing competencies at the beginning of one's nursing practice, which is crucial for patients' outcomes, should be accompanied by the strengthening of novice nurses' self-esteem.KEY MESSAGESNovice nurses with a higher level of self-esteem more often declared their willingness to leave their profession.The results showed a negative correlation between self-esteem and all subscales of the competence scale.Seniority and postgraduate education are important moderators in the relationship between some competence subscales and self-esteem.


Asunto(s)
Intención , Competencia Profesional , Adaptación Psicológica , Estudios Transversales , Humanos , Encuestas y Cuestionarios
10.
Artículo en Inglés | MEDLINE | ID: mdl-35162753

RESUMEN

(1) Background: The COVID-19 pandemic posed a great challenge to health care systems worldwide. Health care personnel, including nurses, work under high pressure and are overworked and overwhelmed, which results in a higher prevalence of burnout and workplace bullying, which further increases the intention to leave the nursing profession. (2) Methods: A comparative correlational and cross-sectional study design was adopted, and an online questionnaire was used to collect data between October 2019 and October 2021. Two hundred and fifty-seven newly graduated nurses participated in this study. The studied variable was measured using the Oldenburg Burnout Inventory, the Negative Acts Questionnaire, and metrics developed by the authors. (3) Results: The prevalence of bullying and burnout is significantly higher among nurses who worked during the COVID-19 pandemic than among those who worked before the pandemic, but the pandemic has not had an impact on the level of the subjective assessment of bullying. Working as a newly graduated nurse before or during the COVID-19 pandemic is a moderator between person-related bullying and its dimensions and disengagement. (4) Conclusions: Pandemics increase bullying and burnout among newly graduated nurses; however, the current challenges have caused some of this to remain unrevealed, the repercussions of which will appear with double strength later.


Asunto(s)
Acoso Escolar , Agotamiento Profesional , COVID-19 , Enfermeras y Enfermeros , Agotamiento Profesional/epidemiología , Estudios Transversales , Atención a la Salud , Humanos , Pandemias , SARS-CoV-2 , Encuestas y Cuestionarios , Lugar de Trabajo
11.
Nurs Crit Care ; 27(3): 326-333, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-33295120

RESUMEN

BACKGROUND: The current literature indicates that intensive care (ICU) patients' sleep quality is generally poor, which is associated with serious physical and psychological consequences. AIMS AND OBJECTIVES: To describe the practices nurses use to provide good-quality sleep to adult ICU patients and assess nurses' perceptions of patients' sleep quality and nurses' professional autonomy in sleep management. DESIGN: A descriptive-correlational, cross-sectional study. METHODS: A total of 232 ICU nurses from four hospitals in Poland were recruited. Data were collected between May and August 2019 using a previously developed questionnaire and analysed using descriptive statistics and non-parametric tests. RESULTS: A total of 119 nurses took part in the study (response rate: 51%). On average, nurses rated patients' sleep quality as moderate (4.44 ± 2.23, scale 0-10). Most of the respondents (95.8%) said they did not use any sleep protocol. Various strategies to improve patients' sleep were used sporadically (2.64 ± 1.55, scale 1-5). The use of sleep quality assessment methods was positively correlated with patients' sleep quality (rho = 0.22, P = .02). Nurses' professional autonomy regarding sleep management was assessed as average (4.34 ± 2.43, scale 0-10) and was correlated with the patients' sleep quality (rho = 0.25, P < .01). Nurses who rated their autonomy in patients' sleep management more highly (rho = 0.29, P < .01) and more often influenced patients' sleep decisions (rho = 0.24, P < .01) used more methods to improve patients' sleep. CONCLUSIONS: Strengthening the professional autonomy of ICU nurses and creating a reliable sleep assessment and improvement tool, which would describe strategies nurses can implement independently could increase sleep quality among ICU patients. RELEVANCE TO CLINICAL PRACTICE: Addressing organizational problems, which hamper the patients' sleep management by ICU nurses could result in using more strategies to provide good-quality sleep to ICU patients. There is a need for clinical guidelines regarding patients' sleep management to help educate and guide nurses how to independently use sleep improvement methods.


Asunto(s)
Enfermeras y Enfermeros , Personal de Enfermería en Hospital , Adulto , Estudios Transversales , Humanos , Unidades de Cuidados Intensivos , Personal de Enfermería en Hospital/psicología , Sueño/fisiología , Calidad del Sueño , Encuestas y Cuestionarios
12.
Nurs Crit Care ; 27(1): 10-18, 2022 01.
Artículo en Inglés | MEDLINE | ID: mdl-33624431

RESUMEN

BACKGROUND: Novice nurses (newly qualified within the first 3-year period of professional practice after registration) must first face the reality and complexity of caring for high-acuity patients in the critical care setting, which can be an unfamiliar and demanding environment. The successful transition from education to professional practice of novice nurses hired for intensive care must be supported. AIM: To explore Polish novice nurses' readiness to practice in an intensive care unit (ICU). Our study objectives included investigating pre-registration preparation for work in an ICU, identifying the most needed competencies to work in an ICU, and analysing organizational aspects of the professional orientation period. STUDY DESIGN: A qualitative phenomenology design was applied. METHODS: We conducted qualitative content analysis based on individual semi-structured in-depth interviews. Study recruitment was performed using a purposeful and network sampling strategy. The final number of participants was 17 Polish novice nurses. RESULTS: The majority of responders replied that they were not prepared to work in an ICU after graduation. Professional orientation was planned-generally for a period of 3 months; however, in most places it was shortened. The respondents identified the five competencies most needed to work in an ICU: communication, teamwork, professional self-confidence, and knowledge and its practical use. Their enhancement could be achieved through simulations during both pre-registration and professional training. CONCLUSION: Analysis of the novice nurses' orientation period revealed many difficulties that indicated a lack of readiness to practice in an ICU after graduation. Identifying novice nurses' strengths and weaknesses regarding clinical competence is important to guide the design of orientation programmes in ICU settings and nursing education programmes. RELEVANCE TO CLINICAL PRACTICE: Readiness for ICU work may be improved by enriching education with simulations that enable training in the practical use of knowledge and critical care procedures. A supportive work environment is crucial during professional orientation.


Asunto(s)
Unidades de Cuidados Intensivos , Enfermeras y Enfermeros , Competencia Clínica , Cuidados Críticos , Humanos , Investigación Cualitativa
13.
BMJ Open ; 11(12): e049787, 2021 12 02.
Artículo en Inglés | MEDLINE | ID: mdl-34857563

RESUMEN

OBJECTIVES: To determine to what degree particular coping strategies mediate the association between stress and insomnia in novice nurses who are employed while continuing their education and how type of education moderate the relationships between workplace stress, coping strategies and insomnia. METHODS: A descriptive cross-sectional study was performed using an online questionnaire, which was completed by 159 novice registered nurses. The questionnaire comprised four components: Athens Insomnia Scale, Perceived Stress at Work (based on Perceived Stress Scale), Brief-Coping Orientation to Problem Experienced (COPE)and metrics with sociodemographic data questions. RESULTS: Stress was found to be a significant predictor of insomnia among novice nurses. After adjusting the coping strategy, work stress ceased to be a significant predictor of insomnia. Among the strategies, the significant predictors that increased severity insomnia were acceptance, denial and self-blame. Predictors that decreased severity insomnia were use of emotional support and venting. Furthermore, the relationship between both active coping and self-distraction strategies and insomnia was significant for part-time students. CONCLUSIONS: Insomnia is significant phenomena among novice nurses and are exacerbated by increased stress in the workplace. Choosing appropriate coping strategies for stress that are dependent on the individuals' activities significantly reduce the severity of insomnia caused by work stress.


Asunto(s)
Trastornos del Inicio y del Mantenimiento del Sueño , Adaptación Psicológica , Estudios Transversales , Humanos , Polonia , Trastornos del Inicio y del Mantenimiento del Sueño/epidemiología , Estrés Psicológico/psicología , Encuestas y Cuestionarios
14.
J Foot Ankle Surg ; 60(5): 902-907, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33820683

RESUMEN

The study aimed to analyze bacterial flora in diabetic foot infection, empiric and targeted antibiotic therapy, and factors influencing wound healing duration. The study we undertook a review analysis of data in 118 cases of diabetic foot among 98 patients who reported to the Wound Care Clinic in Warsaw, Poland between 01/2014 and 12/2018. Collected data included sociodemographic data, wounds information, used treatment, results of the microbiological examination, and empiric and targeted antibiotic therapy. For purposes of identifying the empirical and targeted antibiotic compatibility, the patients were divided into subgroups: ETA+ (compatibility of empiric-targeted antibiotic), ETA- (non-compatibility of empiric-targeted antibiotic), NEA (no empiric antibiotic), and NTA (no targeted antibiotic). The study group consisted of men, N = 71 (72.4%) and women, N = 27 (27.6%). Twenty patients (20.4%) were diagnosed as obese according to the body mass index classification. Staphylococcus aureus and Enterococcus faecalis were identified in most cases [N = 53 (24.4%), and N = 41 (18.9%), respectively]. Sixteen patients (13.6%) received gentamycin locally. Amoxicillin with clavulanic acid, clindamycin, and levofloxacin were the most frequently used antibiotics as empiric therapy; meanwhile, in targeted therapy, amoxicillin with clavulanic acid and levofloxacin were most frequently used. Empiric and targeted antibiotic therapies were compatible in 65 (55.1%) cases. The duration of healing did not differ between selected subgroups, and was longer in obese patients (p = .001). Other variables did not influence the healing time. The use of empiric antibiotic therapy before targeted therapy and the topical use of gentamycin did not reduce the healing time of diabetic foot infection. The healing time of diabetic foot infection was longer in obese patients than in nonobese patients.


Asunto(s)
Diabetes Mellitus , Pie Diabético , Infecciones Estafilocócicas , Antibacterianos/uso terapéutico , Clindamicina , Diabetes Mellitus/tratamiento farmacológico , Pie Diabético/tratamiento farmacológico , Femenino , Humanos , Masculino , Infecciones Estafilocócicas/tratamiento farmacológico , Cicatrización de Heridas
15.
Arch Immunol Ther Exp (Warsz) ; 69(1): 6, 2021 Mar 08.
Artículo en Inglés | MEDLINE | ID: mdl-33683459

RESUMEN

The pathophysiology of rotator cuff tendinopathy is not fully understood, particularly in terms of the local inflammatory process. This study aimed to investigate the expression of selected molecules in the tumour necrosis factor (TNF)-α transduction pathway, including TNF-α, TNF receptor 1 (TNFR1), neutral sphingomyelinase activation associated factor (NSMAF), caspase 3 (Casp3), and interleukin (IL)-8, in patients with rotator cuff tendinopathy that had undergone surgical treatment. We included 44 participants that underwent arthroscopy, due to rotator cuff tendinopathy. Samples from the injured tendon were collected during arthroscopy, and RT-PCR was performed to determine gene expression. Pearson correlation analyses or U-Mann-Whitney test were performed to identify associations with the following parameters: sex, age at admission, body mass index, the presence of night pain, previous treatment (nonsteroidal anti-inflammatory drugs and/or steroids), medical history of the shoulder injury, upper subluxation of the humeral head, and the number of tendons injured. RT-PCR showed that the selected pro-inflammatory factors involved in the TNF-α signalling pathway expression levels were expressed in the tendon tissues. However, the levels of expression varied from patient to patient. Variations were over 250-fold for TNF-α, about 130-fold for TNFR1, NSMAF, and Casp3, and 1000-fold for IL-8. We could not confirm that any of the clinical parameters investigated were associated with the level of gene expression in the TNF-α pathway and IL-8.


Asunto(s)
Lesiones del Manguito de los Rotadores/inmunología , Tendones/inmunología , Factor de Necrosis Tumoral alfa/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Caspasa 3/genética , Femenino , Humanos , Interleucina-8/genética , Péptidos y Proteínas de Señalización Intracelular/genética , Masculino , Persona de Mediana Edad , ARN Mensajero/análisis , Receptores Tipo I de Factores de Necrosis Tumoral/genética , Lesiones del Manguito de los Rotadores/cirugía , Transducción de Señal/fisiología , Factor de Necrosis Tumoral alfa/genética
16.
Int J Mol Sci ; 22(4)2021 Feb 11.
Artículo en Inglés | MEDLINE | ID: mdl-33670100

RESUMEN

Silver-based materials are widely used in clinical medicine. Furthermore, the usage of silver containing materials and devices is widely recommended and clinically approved. The impact on human health of the increasing use of silver nanoparticles in medical devices remains understudied, even though Ag-containing dressings are known to release silver into the bloodstream. In this study, we detected a widespread and sometimes significant silver accumulation both in healthy and sick liver biopsies, levels being statistically higher in patients with various hepatic pathologies. 28 healthy and 44 cirrhotic liver samples were investigated. The median amount of 0.049 ppm Ag in livers was measured in cirrhotic livers while the median was 0.0016 ppm for healthy livers (a more than 30-fold difference). The mean tissue concentrations of essential metals, Fe and Zn in cirrhotic livers did not differ substantially from healthy livers, while Cu was positively correlated with Ag. The serum levels of gamma-glutamyl transpeptidase (GGTP) was also positively correlated with Ag in cirrhotic livers. The increased Ag accumulation in cirrhotic livers could be a side effect of wide application of silver in clinical settings. As recent studies indicated a significant toxicity of silver nanoparticles for human cells, the above observation could be of high importance for the public health.


Asunto(s)
Cobre/metabolismo , Cirrosis Hepática/metabolismo , Trasplante de Hígado , Hígado/metabolismo , Plata/metabolismo , Adulto , Femenino , Humanos , Cirrosis Hepática/cirugía , Masculino , Persona de Mediana Edad
17.
Int J Occup Med Environ Health ; 34(4): 505-512, 2021 Aug 05.
Artículo en Inglés | MEDLINE | ID: mdl-33559650

RESUMEN

OBJECTIVES: Increased life expectancy results in greater challenges posed to healthcare. Concurrently, a shortage of healthcare workforce, including nurses, has been observed. Thus, an urgent need exists to implement improvements in healthcare services based on sufficient evidence. The aim of the study was to evaluate the influence of the relative number of nurses/midwives on life expectancy, and the influence of selected economic variables: gross domestic product (GDP), health expenditure as a percentage of GDP, and health expenditure per capita, on this number. The aim of the study was to evaluate the influence of the relative number of nurses/midwives on life expectancy, and the influence of select economic variables: GDP, health expenditure as a percentage of GDP, and health expenditure per capita on this number. MATERIAL AND METHODS: A retrospective analysis based on data from 46 countries was performed. Correlations between the relative number of nurses/midwives and life expectancy as well as economic variables were evaluated. To trace the differences between the countries with different relative numbers of nurses/ midwives, the countries were divided into groups as follows - group 1: <5 nurses and midwives/1000 nurses inhabitants, group 2: 5-10 nurses and midwives/1000 inhabitants, and group 3: >10 nurses and midwives/1000 inhabitants. RESULTS: Correlations were found between the relative number of nurses/midwives and life expectancy (p < 0.001, r = 0.68), and economic variables (p < 0.001, r = 0.82; p < 0.001, r = 0.62, and p < 0.001, r = 0.8, respectively). Life expectancy was higher in group 3 vs. groups 1 and 2 (p < 0.001 and p = 0.036, respectively), and in group 2 vs. group 1 (p = 0.006). Economic variables were higher in group 3 vs. group 1 (p < 0.001 for all) and group 2 (p = 0.016, p = 0.025, p = 0.022, respectively), and in group 2 vs. group 1 (p = 002, p = 0.024, p = 0.002, respectively). CONCLUSIONS: The relative number of nurses/midwives correlates with life expectancy and relies on the country's income and level of healthcare system financing. Int J Occup Med Environ Health. 2021;34(4):505-12.


Asunto(s)
Partería , Enfermeras y Enfermeros , Femenino , Producto Interno Bruto , Humanos , Esperanza de Vida , Embarazo , Estudios Retrospectivos
18.
J Cancer Educ ; 36(3): 561-566, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-31953802

RESUMEN

Providing care for dying patients and their families is an important skill for the nursing profession. The attitude of persons working with a dying person plays an important role in the quality of care provided. In this context, comprehensive preparation of medical staff for care giving to dying patient is very important. No scientific research based on the Frommelt Attitudes Toward Care of the Dying Scale form B has been done in Poland. The study aimed at translations, assessments of credibility, and reliability of psychometric properties of the Polish version of the questionnaire of Frommelt Attitudes Toward Care of the Dying Scale form B (FATCOD-BP). The study included 107 students of the Nursing Department at Medical University of Warsaw. The validation was performed with the use of Cronbach's alpha coefficient, Horn's parallel analysis, Kaiser-Meyer-Olkin index, and Bartlett's sphericity test. The result of Cronbach's alpha for FATCOD-BP was a = 0.725. Kaiser-Meyer-Olkin index equaled 0.696. Bartlett's sphericity test was p < 0.001. The FATCOD-BP scale is characterized by a high index of reliability. Reciprocal correlations occur between variables introduced into the model. The FATCOD-BP scale is an appropriate research tool for conducting further studies in nurses in Poland.


Asunto(s)
Estudiantes de Enfermería , Cuidado Terminal , Actitud del Personal de Salud , Actitud Frente a la Muerte , Humanos , Lenguaje , Cuidados Paliativos , Polonia , Psicometría , Reproducibilidad de los Resultados , Encuestas y Cuestionarios
19.
J Geriatr Psychiatry Neurol ; 34(1): 29-36, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-31996080

RESUMEN

We investigated quality of life (WHOQoL-BREF), perceived stress (PSS-10), anxiety and depression (HADS-M), life satisfaction (SWLS), and serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and cortisol in family caregivers (n = 94) and professional caregivers (n = 48) of demented patients, as well as among noncaregivers (n = 30). Compared with professional caregivers, family caregivers had higher scores in HADS-M depression (P = .003) and anxiety (P = .033), lower life satisfaction (P = .04), and lower quality of life in psychological (P = .02) and social relationship (P = .03) domains. There were no differences in serum levels of IL-6, CRP, or cortisol between caregivers and control participants. In multivariable analysis, when family relationship was considered together with the time period of caregiving and results of the Mini-Mental State Examination test in care recipients (n = 118, 12.49 ± 7.99), only family relationship influenced scores in HADS-M depression (P = .004), SWLS scores (P = .011), and WHOQoL-BREF scores in psychological (P = .011) and social relationship (P = .008) domains. In conclusion, family caregivers are more stressed and have deeper depressive and anxiety disorders, lower life satisfaction, and lower quality of life than professional caregivers.


Asunto(s)
Cuidadores/psicología , Demencia , Depresión/epidemiología , Familia/psicología , Calidad de Vida/psicología , Estrés Psicológico/psicología , Adaptación Psicológica , Anciano , Ansiedad/epidemiología , Ansiedad/etiología , Depresión/psicología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Satisfacción Personal
20.
Phlebology ; 36(4): 275-282, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33045907

RESUMEN

OBJECTIVE: The aim of the study was to analyze bacterial flora in venous leg ulcers, empiric and targeted antibiotic therapy, and factors influencing healing time. MATERIALS AND METHODS: Data from 30 patients with venous leg ulcers were retrospectively analyzed. Collected data included: sociodemographic data, wounds information, number of comorbidities, results of the microbiological examination, and empiric and targeted antibiotic therapy. To compare the empiric and targeted treatment in terms of their compatibility, the group of patients was divided into the four subgroups: NEA (no empiric antibiotics), NA (no antibiotics), ETA+ (compatibility of empiric and targeted antibiotic), ETA- (no compatibility of empiric and targeted antibiotic). RESULTS: The average ulcer healing time was 163.4 ± 97.1 (range 51.0 to 426.0) days and increased by 28 days with each additional bacterial strain in the ulcer (p = 0.041). Healing time did not differ between the four groups. Staphylococcus aureus and Pseudomonas aeruginosa were the most frequent bacteria. Amoxicillinium/acidum clavulanicum was the most common empirical antibiotic and amoxicillinium/acidum clavulanicum, and levofloxacinum was the most common targeted antibiotic. CONCLUSIONS: Venous leg ulcer healing time was prolonged with each subsequent bacterial strain in the ulcer, and it was independent from systemic antibiotic therapy.


Asunto(s)
Úlcera de la Pierna , Úlcera Varicosa , Bacterias , Humanos , Úlcera de la Pierna/tratamiento farmacológico , Úlcera de la Pierna/epidemiología , Estudios Retrospectivos , Úlcera , Úlcera Varicosa/tratamiento farmacológico , Úlcera Varicosa/epidemiología , Cicatrización de Heridas
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